Inconsistently Heinous villains who undergo mutations.
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- Te Kā
- Terry Akers
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- Thanos (Marvel Cinematic Universe)
- Thanos (Marvel)
- The Black Mass
- The Blob (The Simpsons)
- The Darkness (Supernatural)
- The Forsaken
- The Goblin (2010 Marvel Animated Universe)
- The Horned Serpent
- The Nowhere King
- The Spider-Man
- The Warden Unit
- Theodora (Oz the Great and Powerful)
- Tom (Eddsworld)
- Twisted Alice